DAP_CAT

Epidemiologic Research Group in Diabetes from Primary Health Care

The research team is made up of professionals from various disciplines and we focus our research on the study of diabetes and its complications, both in the hospital and primary care setting, demonstrating a great capacity to generate projects and publications in recent years. The main lines of research of the group are two: a) Complications of diabetes: atherosclerosis and microvascular disease, as the main causes of morbimortality. b) Epidemiology of diabetes: research in primary care and use of large databases. In recent years, the group has developed projects using the SIDIAP database on different aspects of diabetes in real-world evidence. The group is a pioneer at the national level in this area and has active collaborations with international groups. In the last 5 years the group has published 189 articles of which 94 are in Q1 (50%) and 27 in D1 (14%). The average impact factor of the articles is 4.78 and 2801 citations.

Group projects

PI: Franch Nadal, Josep. ImpactT2D: una estrategia genómica para implementar medicina de precisión en la diabetes tipo 2. Funding: Instituto de Salud Carlos III. Duration: 2022 - 2025

PI: Mata Cases, José Manuel. Identificación de Factores predictores de Mal Pronóstico identificables ya en el momento del diagnóstico de la COVID-19 en Atención Primaria. ¿Varían en cada una de las ondas epidémicas?. Funding: Instituto de Salud Carlos III. Duration: 2022 - 2024

PI: Mauricio Puente, Dídac. Caracterización de subgrupos de diabetes mellitus tipo 2 al diagnóstico: un paso necesario hacia la medicina de precisión en diabetes, estudio COPERNICAN. Funding: Institut de Recerca Hospital de la Santa Creu i Sant Pau. Duration: 2022 - 2024

PI: Hernández García, Marta. Diagnóstico de diabetes gestacional en Catalunya durante el periodo de Ramadán. Funding: IDIAP Jordi Gol. Duration: 2022 - 2024

PI: Franch Nadal, Josep. Aportacions de la genètica a la caracterització de una cohort de Medicina Personalitzada de Precisió en el moment del debut de la diabetis. Funding: Departament de Salut. Duration: 2022 - 2024

PI: Franch Nadal, Josep. Aportacions de la genètica a la caracterització de una cohort de Medicina Personalitzada de Precisió en el moment del debut de la diabetis. Funding: Departament de Salut. Duration: 2022 - 2024

PI: Ramírez Morros, Anna Mª. Estudi descriptiu de les característiques clíniques i l'abordatge terapèutic dels factors de risc cardiovascular al debut de la diabetis tipus 2 (DM2) en funció del sexe en una cohort d'atenció primària a Catalunya.. Funding: IDIAP Jordi Gol. Duration: 2022 - 2024

PI: Franch Nadal, Josep. A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients who Initiated Exenatide as Compared with those who Initiated Other non-Glucagon-Like Peptide 1 Receptor Agonists based Glucose Lowering Drugs (EXCEED). Funding: IQVIA LTD. Duration: 2020 - 2024

PI: Mauricio Puente, Dídac. International diabetes federation diabetes atlas data from Catalonian population database. Funding: ICS - Institut Català de la Salut. Duration: 2021 - 2023

PI: Franch Nadal, Josep. A Real-World Database Study of Canagliflozin Utilization in Type 1 Diabetes Patients Over Time among European Countries. Funding: Janssen Research & Development, LLC. Duration: 2021 - 2023

PI: Mata Cases, José Manuel. Evolución de control metabólico de la diabetes tipo 2 en atención primaria de Cataluña. Funding: ICS - Institut Català de la Salut. Duration: 2021 - 2023

PI: Franch Nadal, Josep. Gestational diabetes and complications among pregnant women attended in primary care sexual and reproductive health services in Catalonia. Funding: . Duration: 2021 - 2023

PI: Franch Nadal, Josep. Impacto de la diabetes y la obesidad en la infección por SARS-CoV-2: Identificación de factores pronóstico y creación de un score predictivo basado en técnicas de inteligencia artificial. Funding: IDIAP Jordi Gol. Duration: 2021 - 2023

PI: Franch Nadal, Josep. ContRol de la diabEteS tipo 2 En tIempoS de pandemia COVID-19 en centros de aTención primaria. Estudio RESIST. Funding: Redgedaps, s.l.. Duration: 2021 - 2022

PI: Soldevila Madorell, Berta. Epidemiologia de diabetis gestacional i d'alteracions glucèmiques en el postpart a Catalunya. Estudi epiDMGCAT. Funding: IDIAP Jordi Gol. Duration: 2020 - 2022

PI: Mauricio Puente, Dídac. Epidemiología de SARS-CoV-2 en personas con obesidad y/o diabetes mellitus en Cataluña - Estudio epiCOVID19DMO. Funding: IDIAP Jordi Gol. Duration: 2020 - 2022

PI: Ortega Martínez de Victoria, Emilio. Epidemiología de la hipertrigliceridemia grave y su relación con la incidencia de pancreatitis aguda y enfermedad cardiovascular en Cataluña. Funding: IDIAP Jordi Gol. Duration: 2020 - 2022

The group participates in the following projects

PI: Cabré Vila, Juan José. Estudio económico de recursos consumidos en la traslación hacia atención primaria de un programa preventivo de la diabetes mediante intervención sobre estilo de vida (DP-TRANSFERS-Eco). Funding: Instituto de Salud Carlos III. Duration: 2020 - 2022

PI: Puente Baliarda, Diana. Síndrome metabólico y riesgo de cáncer: estudio caso-control con datos del Sistema de Información para el Desarrollo de la Investigación en Atención Primaria (SIDIAP) en Cataluña. Funding: Instituto de Salud Carlos III. Duration: 2018 - 2022

Group publications

Antonio-Arques V, Caylà JA, Real J, Moreno-Martinez A, Orcau À, Mauricio D, Mata-Cases M, Julve J, Navas Mendez E, Puig Treserra R, Millet JP, Del Val García JL, Vlacho B, Franch-Nadal J. Glycemic control and the risk of tuberculosis in patients with diabetes: A cohort study in a Mediterranean city. Front Public Health. 2022 ; 10:1017024. doi:10.3389/fpubh.2022.1017024. Epub 2022 Nov 17. pmc:PMC9713231. PMID:36466495. IF: .

Antonio-Arques V, Franch-Nadal J, Moreno-Martinez A, Real J, Orcau À, Mauricio D, Mata-Cases M, Julve J, Navas Mendez E, Puig Treserra R, Barrot de la Puente J, Millet JP, Del Val García JL, Vlacho B, Caylà JA. Subjects With Diabetes Mellitus Are at Increased Risk for Developing Tuberculosis: A Cohort Study in an Inner-City District of Barcelona (Spain). Front Public Health. 2022 ; 10:789952. doi:10.3389/fpubh.2022.789952. Epub 2022 May 23. pmc:PMC9168433. PMID:35677764. IF: .

Barrot J, Real J, Vlacho B, Romero-Aroca P, Simó R, Mauricio D, Mata-Cases M, Castelblanco E, Mundet-Tuduri X, Franch-Nadal J. Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes. Front Med (Lausanne). 2022 ; 9:945245. doi:10.3389/fmed.2022.945245. Epub 2022 Aug 16. pmc:PMC9424917. PMID:36052329. IF: .

Bundó M, Vlacho B, Llussà J, Puig-Treserra R, Mata-Cases M, Cos X, Jude EB, Franch-Nadal J, Mauricio D. Prevalence and risk factors of diabetic foot disease among the people with type 2 diabetes using real-world practice data from Catalonia during 2018. Front Endocrinol (Lausanne). 2022 ; 13:1024904. doi:10.3389/fendo.2022.1024904. Epub 2022 Oct 24. pmc:PMC9637660. PMID:36353236. IF: 5,555.

Castelblanco E, Granado-Casas M, Hernández M, Pinyol M, Correig E, Julve J, Rojo-López MI, Alonso N, Avogaro A, Ortega E, Mauricio D. Diabetic retinopathy predicts cardiovascular disease independently of subclinical atherosclerosis in individuals with type 2 diabetes: A prospective cohort study. Front Cardiovasc Med. 2022 ; 9:945421. doi:10.3389/fcvm.2022.945421. Epub 2022 Nov 03. pmc:PMC9668891. PMID:36407461. IF: 6,050.

Castelblanco E, Hernández M, Alonso N, Ribes-Betriu A, Real J, Granado-Casas M, Rossell J, Rojo-López MI, Dusso AS, Julve J, Mauricio D. Association of ?-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus. Cardiovasc Diabetol. 2022 Oct; 21(1):207. doi:10.1186/s12933-022-01640-3. Epub 2022 Oct 11. pmc:PMC9554979. PMID:36221075. IF: .

Colomer FA, Cugat MÀC, Bort-Roig J, Chirveches-Pérez E, Zaldúa YC, Martín-Cantera C, Franch-Nadal J, Puig-Ribera A. Differences in Free-Living Patterns of Sedentary Behaviour between Office Employees with Diabetes and Office Employees without Diabetes: A Principal Component Analysis for Clinical Practice. Int J Environ Res Public Health. 2022 Sep; 19(19). doi:10.3390/ijerph191912245. Epub 2022 Sep 27. pmc:PMC9566776. PMID:36231564. IF: .

Franch-Nadal J, Gatius JR, Mata-Cases M, Ortega E, Valles JA, Vlacho B, Mauricio D. Compliance with the DPP-4 inhibitors dose adjustment recommendations based on renal function in a population database. Endocrinol Diabetes Nutr (Engl Ed). 2022 Feb; 69(2):83-91. doi:10.1016/j.endien.2022.02.011. Epub 2022 Feb 28. PMID:35256063. IF: 1,417.

Franch-Nadal J, Granado-Casas M, Mata-Cases M, Ortega E, Vlacho B, Mauricio D. Determinants of response to the glucagon-like peptide-1 receptor agonists in a type 2 diabetes population in the real-world. Prim Care Diabetes. 2022 Dec; 16(6):810-817. doi:10.1016/j.pcd.2022.10.005. Epub 2022 Nov 03. PMID:36336605. IF: 2,459.

Gabriel GP, Bogdan V, Elena N, Manel MC, Jordi R, Xavier C, Josep FN, Didac M. Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area. Diabetes Res Clin Pract. 2022 Aug; doi:10.1016/j.diabres.2022.110031. Epub 2022 Aug 04. PMID:35934173. IF: 5,602.

Gómez-Huelgas R, Gómez-Peralta F, Cos FX. Evaluation of knowledge, barriers, and attitudes in the management of type 2 diabetes in elderly patients: A Delphi study on primary and hospital care. Rev Clin Esp (Barc). 2022 ; 222(7):385-392. doi:10.1016/j.rceng.2021.11.007. Epub 2022 Mar 14. PMID:35300934. IF: .

Jiménez-Balado J, Riba-Llena I, Nafría C, Pizarro J, Rodríguez-Luna D, Maisterra O, Ballvé A, Mundet X, Violan C, Ventura O, Montaner J, Delgado P. Silent brain infarcts, peripheral vascular disease and the risk of cardiovascular events in patients with hypertension. J Hypertens. 2022 Aug; 40(8):1469-1477. doi:10.1097/HJH.0000000000003154. Epub 2022 Jul 05. PMID:35881448. IF: 4,844.

Khunti K, Jabbour S, Cos X, Mudaliar S, Mende C, Bonaca M, Fioretto P. Sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes: Barriers and solutions for improving uptake in routine clinical practice. Diabetes Obes Metab. 2022 Jul; 24(7):1187-1196. doi:10.1111/dom.14684. Epub 2022 Mar 30. pmc:PMC9313799. PMID:35238129. IF: 6,577.

Ling S, Zaccardi F, Vlacho B, Li P, Real Gatius J, Mata-Casas M, Franch-Nadal J, Kosiborod MN, Gillies C, Fenici P, Mauricio D, Shah BR, Khunti K. All-cause and cardiorenal mortality in 6 million adults with and without type 2 diabetes: a comparative, trend analysis in Canada, Spain, and the UK. Diabetes Obes Metab. 2022 Sep; doi:10.1111/dom.14856. Epub 2022 Sep 03. PMID:36056765. IF: 6,577.

Llauradó G, Vlacho B, Wargny M, Ruan Y, Franch-Nadal J, Domingo P, Gourdy P, Saulnier PJ, Hadjadj S, Wild SH, Rea R, Cariou B, Khunti K, Mauricio D; CORONADO, the ABCD COVID-19 diabetes national audit, HM Hospitales investigators and the Hospital del Mar - Hospital de la Santa Creu i Sant Pau Diabetes Research Group. The association between macrovascular complications and intensive care admission, invasive mechanical ventilation, and mortality in people with diabetes hospitalized for coronavirus disease-2019 (COVID-19). Cardiovasc Diabetol. 2022 Oct; 21(1):216. doi:10.1186/s12933-022-01657-8. Epub 2022 Oct 19. pmc:PMC9580453. PMID:36261811. IF: .

Manouchehri M, Cea-Soriano L, Franch-Nadal J, Ruiz A, Goday A, Villanueva R, Diez-Espino J, Mata-Cases M, Giraldez-García C, Regidor E; PREDAPS Study Group. Heterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up. Sci Rep. 2022 May; 12(1):7373. doi:10.1038/s41598-022-11392-5. Epub 2022 May 05. pmc:PMC9072306. PMID:35513560. IF: 4,379.

Manzini E, Vlacho B, Franch-Nadal J, Escudero J, Génova A, Reixach E, Andrés E, Pizarro I, Portero JL, Mauricio D, Perera-Lluna A. Longitudinal deep learning clustering of Type 2 Diabetes Mellitus trajectories using routinely collected health records. J Biomed Inform. 2022 Oct; doi:10.1016/j.jbi.2022.104218. Epub 2022 Oct 07. PMID:36216232. IF: 6,317.

Martinez-Gonzalez D, Dòria M, Martínez-Alonso M, Alcubierre N, Valls J, Verdú-Soriano J, Granado-Casas M, Mauricio D. Correction: Martinez-Gonzalez et al. Adaptation and Validation of the Diabetic Foot Ulcer Scale-Short Form in Spanish Subjects. 2020, , 2497. J Clin Med. 2022 Oct; 11(19). doi:10.3390/jcm11195963. Epub 2022 Oct 10. pmc:PMC9572715. PMID:36233845. IF: .

Mata-Cases M, Mauricio D, Real J, Vlacho B, Romera-Liebana L, Molist-Brunet N, Cedenilla M, Franch-Nadal J. Potential Risk of Overtreatment in Patients with Type 2 Diabetes Aged 75 Years or Older: Data from a Population Database in Catalonia, Spain. J Clin Med. 2022 Aug; 11(17). doi:10.3390/jcm11175134. Epub 2022 Aug 31. pmc:PMC9457074. PMID:36079064. IF: .

Mauricio D, Vlacho B, Ortega E, Cos-Claramunt X, Mata-Cases M, Real J, Fernandez-Camins B, Franch-Nadal J. Outcome of COVID-19 infection in people with diabetes mellitus or obesity in the primary care setting in Catalonia, Spain: A retrospective cohort study of the initial three waves. Prim Care Diabetes. 2022 Dec; doi:10.1016/j.pcd.2022.12.002. Epub 2022 Dec 08. pmc:PMC9729647. PMID:36528549. IF: 2,459.

Ramírez-Morros A, Franch-Nadal J, Real J, Gratacòs M, Mauricio D. Correction: Ram?rez-Morros et al. Sex Differences in Cardiovascular Prevention in Type 2: Diabetes in a Real-World Practice Database. 2022, , 2196. J Clin Med. 2022 Aug; 11(15). doi:10.3390/jcm11154492. Epub 2022 Aug 02. pmc:PMC9370015. PMID:35956255. IF: .

Ramírez-Morros A, Franch-Nadal J, Real J, Gratacòs M, Mauricio D. Sex Differences in Cardiovascular Prevention in Type 2: Diabetes in a Real-World Practice Database. J Clin Med. 2022 Apr; 11(8). doi:10.3390/jcm11082196. Epub 2022 Apr 14. pmc:PMC9032335. PMID:35456292. IF: .

Romero-Aroca P, López-Galvez M, Martinez-Brocca MA, Pareja-Ríos A, Artola S, Franch-Nadal J, Fernandez-Ballart J, Andonegui J, Baget-Bernaldiz M. Changes in the Epidemiology of Diabetic Retinopathy in Spain: A Systematic Review and Meta-Analysis. Healthcare (Basel). 2022 Jul; 10(7). doi:10.3390/healthcare10071318. Epub 2022 Jul 16. pmc:PMC9320037. PMID:35885844. IF: .

Ruiz PLD, Chen L, Morton JI, Salim A, Carstensen B, Gregg EW, Pavkov ME, Mata-Cases M, Mauricio D, Nichols GA, Pildava S, Read SH, Wild SH, Shaw JE, Magliano DJ. Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts. Diabetologia. 2022 Mar; doi:10.1007/s00125-022-05659-9. Epub 2022 Mar 22. PMID:35314870. IF: 10,122.

Sánchez E, Kerkeni M, Hernández M, Gavaldà R, Rius F, Sauret A, Torres G, Bermúdez-López M, Fernández E, Castro-Boqué E, Purroy F, Mauricio D, Farràs-Sallés C, Buti M, Godoy P, Pamplona R, Lecube A. Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study. Nutrients. 2022 Mar; 14(5). doi:10.3390/nu14051102. Epub 2022 Mar 05. pmc:PMC8912766. PMID:35268075. IF: .

Seidu S, Cos X, Brunton S, Harris SB, Jansson SPO, Mata-Cases M, Neijens AMJ, Topsever P, Khunti K. 2022 update to the position statement by Primary Care Diabetes Europe: a disease state approach to the pharmacological management of type 2 diabetes in primary care. Prim Care Diabetes. 2022 Apr; 16(2):223-244. doi:10.1016/j.pcd.2022.02.002. Epub 2022 Feb 16. PMID:35183458. IF: 2,459.

Sierra A, Otero S, Rodríguez E, Faura A, Vera M, Riera M, Palau V, Durán X, Costa-Garrido A, Sans L, Márquez E, Poposki V, Franch-Nadal J, Mundet X, Oliveras A, Crespo M, Pascual J, Barrios C. The GenoDiabMar Registry: A Collaborative Research Platform of Type 2 Diabetes Patients. J Clin Med. 2022 Mar; 11(5). doi:10.3390/jcm11051431. Epub 2022 Mar 05. pmc:PMC8911424. PMID:35268522. IF: .

Valdés S, Doulatram-Gamgaram V, Maldonado-Araque C, Lago-Sampedro A, García-Escobar E, García-Serrano S, García-Vivanco M, Garrido Juan L, Theobald MR, Gil V, Martín-Llorente F, Ocon P, Calle-Pascual A, Castaño L, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbés J, Chaves FJ, Galán-García JL, Aguilera-Venegas G, Gutierrez-Repiso C, Fernández-García JC, Colomo N, Soriguer F, García-Fuentes E, Rojo-Martínez G. Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study). Environ Health. 2022 Aug; 21(1):76. doi:10.1186/s12940-022-00889-1. Epub 2022 Aug 17. pmc:PMC9387071. PMID:35978396. IF: .

Viladés-Medel D, Dégano IR, Subirana I, Descalzo M, Padilla M, Mundet X, Carreras Costa F, Alomar Serrallach X, Camps A, Elosua R, Marrugat J, Leta Petracca R. Usefulness of Cardiac Computed Tomography in Coronary Risk Prediction: A Five-Year Follow-Up of the SPICA Study (Secure Prevention with Imaging of the Coronary Arteries). J Clin Med. 2022 Jan; 11(3). doi:10.3390/jcm11030533. Epub 2022 Jan 21. pmc:PMC8836950. PMID:35159985. IF: .

Vlacho B, Simarro FL, Mata-Cases M, Miravet S, Escribano-Serrano J, Asensio D, Cortes X, Franch-Nadal J. Adherence to antidiabetic treatment among patients managed in primary care centres in Spain: the INTENSE study. Prim Care Diabetes. 2022 Dec; 16(6):760-767. doi:10.1016/j.pcd.2022.10.004. Epub 2022 Nov 02. PMID:36335018. IF: 2,459.

The group participates in the following publications

Gonzalez-Loyola FE, Muñoz MA, Navas E, Real J, Vinyoles E, Verdú-Rotellar JM. Burden of heart failure in primary healthcare. Aten Primaria. 2022 Jun; 54(8):102413. doi:10.1016/j.aprim.2022.102413. Epub 2022 Jun 28. PMID:35777242. IF: 1,137.

Lapena C, Continente X, Sánchez Mascuñano A, Mari dell'Olmo M, López MJ. Effectiveness of a community intervention to reduce social isolation among older people in low-income neighbourhoods. Eur J Public Health. 2022 Oct; 32(5):677-683. doi:10.1093/eurpub/ckac100. pmc:PMC9527970. PMID:36074028. IF: 3,367.

López-Jiménez T, Duarte-Salles T, Plana-Ripoll O, Recalde M, Xavier-Cos F, Puente D. Association between metabolic syndrome and 13 types of cancer in Catalonia: A matched case-control study. PLoS One. 2022 ; 17(3):e0264634. doi:10.1371/journal.pone.0264634. Epub 2022 Mar 04. pmc:PMC8896701. PMID:35245317. IF: 3,240.

Roca Lahiguera D, Bilbeny de Fortuny B, Clusa Gironella T, Fuertes Rodriguez T, Silva Ruiz P, Franch-Nadal J; Grupo de Estudio del Sinhogarismo (GES) del CAP Raval Sud. [Analysis of the homeless population health in a disadvantaged district of Barcelona: ESSELLA study]. Aten Primaria. 2022 Oct; 54(10):102458. doi:10.1016/j.aprim.2022.102458. Epub 2022 Sep 19. Spanish. pmc:PMC9493295. PMID:36137444. IF: 1,137.

Roso-Llorach A, Serra-Picamal X, Cos FX, Pallejà-Millán M, Mateu L, Rosell A, Almirante B, Ferrer J, Gasa M, Gudiol C, Moreno AM, Morales-Rull JL, Rexach M, Sabater G, Auguet T, Vidal F, Lerida A, Rebull J, Khunti K, Argimon JM, Paredes R. Evolving mortality and clinical outcomes of hospitalized subjects during successive COVID-19 waves in Catalonia, Spain. Glob Epidemiol. 2022 Jan; doi:10.1016/j.gloepi.2022.100071. Epub 2022 Jan 07. pmc:PMC8739818. PMID:35018339. IF: .

Indicators

Indicator

2022

Researchers with PhD

10

Total number of projects in which group members have participated

21

Total number of projects in which the PI of the project has belonged to the group

15

Total Funding

749.942,14€

Scientific publications in indexed journals

18

Total Impact factor

76.16

Nº of articles in Q1 journals

9

Q1 IF

54,546

Nº of articles in Q2 journals

2

Q2 IF

8,084
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